Datura is occasionally used as a hallucinogenic drug. It can be consumed by eating the seeds and leaves or smoking them. Some users have also reported making infusions.
Despite the many dangers inherent in its use, Datura is not considered a controlled substance and its cultivation is legal. Datura Stramonium is used in alternative medicine in homeopathic doses (highly diluted).
In India, Datura was used to produce poison but also as an aphrodisiac. In Europe it served as an ingredient in traditional medicine and known as one of the "witches' herbs".
Some Datura users reported not remembering taking it at all, and being unable to distinguish between hallucinations and reality. Most recount a dark and frightening experience; loss of self-identity and ability to speak.
Datura’s effects are impossible to predict due to its variable concentrations of alkaloids. Hence providing any kind of “safe” dosage is challenging. The effects can last up to two days, and the experience can be overwhelming and uncomfortable. Physical effects may include dry mouth, eyes, and skin; increased heart rate and temperature; sensitivity to touch; blurred vision; dizziness; and nausea.
Mental effects include agitation, paranoia and fear, along with depersonalization, amnesia, and increased suggestibility.